Day 1 Cincinnati, OH
Welcome to Cincinnati where you’ll find the largest collection of nineteenth century Italianate architecture in the country. As you disembark, take some time to visit the numerous National Historic Sites via walking tours through Cincinnati’s oldest neighborhoods filled with eclectic architecture. Visit the William Howard Taft National Historic Museum, the National Underground Railroad Freedom Center and Betts House, to name a few.

Day 2 Madison, IN
This colorful, once bustling river port, known as the “19th-century Williamsburg of America,” is a veritable who’s who of historic places and intriguing Federal and Greek Revival-style architecture. Learn about the river rapid industrial growth and decline and visit intriguing museums such as the Lanier Mansion. Also be sure to tour the historic workplace of the Schroeder Saddletree Factory and Museum. Perhaps you’ll also catch the powerboat racing regatta, an annual event and tradition dating back to 1911. 

Day 3 Louisville, KY
Whether you’re a fan of horse racing or not, you’re sure to know what makes Louisville, Kentucky a popular destination for travelers. Named after King Louis XVI of France, Louisville is best known for the famed Kentucky Derby, the first leg of the Triple Crown of Thoroughbred Racing and also known as “The Most Exciting Two Minutes in Sports.” When you visit, you’ll also discover why Louisville is often referred to as either the northernmost Southern city or the southernmost Northern city in the United States, with prevalent influences from both Southern and Midwestern cultures. 

Day 4 Mt. Vernon, IN / Henderson, KY
Named after Washington’s home on the Potomac and located near the country’s first religious commune – New Harmony – this bucolic river town is steeped in fascinating lore. A private guide will take you through the famous first president’s home and grounds. From there, you can choose to visit the numerous historic sites that the river town boasts such as The Posey County Courthouse Square, Downtown Historic District, and the William Gonnermann House. 

You won’t miss the presence of notable resident naturalist, John James Audubon, whose “Birds of America” paintings are re-created in bronze statues located throughout Henderson. Join in on the fun and celebrate the music of another famous resident at the yearly W.C. Handy Blues & Barbeque Festival, one of several well-known annual festivals held in Henderson.
 
Day 5 Cave In Rock, IL
Infamous for being the historic hiding place for outlaws, bandits and river pirates, Cave in Rock, now the center piece of a lush state park, sits high on the bluffs overlooking the Ohio River. A local expert will bring to life this notorious limestone hideout and will reveal interesting facts about the landmark, including that it once served as a backdrop for a movie scene out of How the West Was Won, the 1962 American epic Western film. 

Day 6 Paducah, KY
Located at the confluence of the Tennessee River and the Ohio River, and halfway between St. Louis and Nashville, Paducah will have you feeling as if you stepped back in time as you walk the streets of this Chicasaw village site. Discover Paducah’s rich history by exploring the Wall to Wall mural program, a collection of over 50 murals that covers a number of subjects including Native American history, the Civil War and various industries and area landmarks such as the old Carnegie Library.

Day 7 Cape Girardeau, MO
Enjoy the charming features of this historic town that was once a French trading post and lively river port in the late 1800s. Today it boasts Civil War sites and a tranquil setting commemorating the Cherokee Trail of Tears. Marvel at the outdoor murals reflecting the area's rich history and heritage and enjoy shore excursions to Cape River Heritage Museum and the Red House Interpretive Center.

Day 8 St. Louis, MO
Reflect upon the role St. Louis played in the opening of the American frontier as you cruise past the famed Gateway Arch Riverfront, the tallest man-made monument in the U.S. Get settled in and acquainted at a festive cocktail event with a welcome from the captain as you prepare for a trip down the Mississippi to the Ohio River, one of the most picturesque waterways in the country.

Experience the picturesque waterways of the Mississippi and Ohio Rivers on American Cruise Lines’ brand new Mississippi Riverboat, Queen of the Mississippi. As a passenger on the Queen of the Mississippi, you can expect to step back in time to the grand era of steamboating on the greatest paddlewheeler to ever grace the Mississippi River. While the churn of the paddlewheel blends with the sounds of the river, you’ll rediscover the America of the pioneers, the America of boundless optimism and unlimited possibilities. This journey allows you to experience the rich heritage, fascinating culture, and astounding marvels right in your own backyard.

• Dining service, snacks and complimentary cocktail parties.
• Oversized staterooms – largest in industry.
• Most with private balconies.
• Flat screen satellite TV and DVD players in all staterooms.
• Wireless internet access shipwide.
• Hairdryers in all staterooms.
• Individual climate control in all staterooms.

Category A cabin onboard the Queen of the Mississippi

• Cabin upgrades are available.
• Itinerary is subject to change.
• Fares do not include shore tours, gratuities, or port charges and fees of $250 per person.
• Please ask your Vacations To Go travel counselor for more information

For American Cruise Lines terms and conditions, please click here.

* The prices shown are U.S. dollars per person, based on double occupancy, and subject to availability. Prices quoted for land/cruise arrangements are subject to increase without notice. Once we have received your deposit, land/cruise prices are guaranteed. Air prices quoted via phone or email are subject to increase and are guaranteed only from the time that full payment is received. Also, air prices or air promotions mentioned on this site or on the phone do not include baggage fees imposed by airlines.