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Panama Vacations

Panama, uniquely situated as a land bridge connecting North and South America, is famed for the Panama Canal that links the world's largest oceans. Many Panama tours visit the Miraflores Locks on the canal's Pacific entrance. Here, you can see millions of gallons of water transferred in mere minutes, all done by gravity.

Itineraries can also feature nocturnal wildlife cruises along the Chagres River and Gatun Lake, in search of howler monkeys, toucans and myriad reptiles; aerial tram tours through the forest canopy in Soberania National Park; and opportunities to meet the self-governing, indigenous Kuna people in the San Blas archipelago.

Book Now and Save on Panama Vacations!

  • Save $100 to $1,000 per couple off select Collette trips. Expires January 31. Click here for eligible departures.
  • Receive a free two-category stateroom upgrade on 2018 Scenic cruises when you book a balcony suite. Click here for eligible departures.
  • Hot deals! Save $500 to $1,500 per couple off select Collette tours. Expires January 31. Click here for eligible departures.
  • Save $600 per couple off select Alexander+Roberts itineraries when you pay in full at the time of booking. Click here for eligible departures.
  • Save up to 25% off with early booking discounts on select Hurtigruten Explorer voyages. Click here for eligible departures.
  • Single travelers save $300 per person off select Alexander+Roberts trips when you book and pay in full. Click here for eligible departures.
  • Collette Passport Club members save an additional $100 to $150 per person off select Collette tours. Offer applies to guests who have traveled with Collette within the past two years and is combinable with other discounts. Click here for eligible departures.
  • Military members and their spouses save 5% off Scenic cruises. This offer does not apply to certain extensions. Click here for eligible departures.
  • Monograms Journeys Club members save 5% off the cruise/land price. Click here for eligible departures.
  • Save $200 per person when you book a group of six or more people on the same Alexander + Roberts trip. Other savings amounts are available for groups of three or more. Click here for eligible departures.

The vacations below are divided into two groups. First, there is a list of trips that visit only Panama, followed by a list of multi-country itineraries that include Panama.

Trips are rated according to the quality of accommodations, the number of included amenities and activities, and the level of service delivered. The vacations below are categorized according to the industry rating scale (budget, first class and deluxe). Click any vacation name for the itinerary, dates and prices.

Vacation Name Days Starts In Ends In Travel Style Company Quality*  
Vacations in Panama Only

Discover Panama 9 Gamboa, Panama  Playa Bonita, Panama  Escorted Collette Deluxe Dates and Prices
Discover Panama (Itinerary B) 9 Gamboa, Panama  Playa Bonita, Panama  Escorted Collette Deluxe Dates and Prices
The Complete Panama Canal 9 Panama City, Panama  Playa Bonita, Panama  Escorted A+R Deluxe Dates and Prices
Discover Panama (Itinerary A) 9 Gamboa, Panama  Playa Bonita, Panama  Escorted Collette Deluxe Dates and Prices
Best of Panama 8 Panama City, Panama  Panama City, Panama  Escorted G Adventure Budget Dates and Prices
The Complete Panama Canal 9 Panama City, Panama  Playa Bonita, Panama  Escorted A+R Deluxe Dates and Prices
5 Day Panama 5 Panama City, Panama  Panama City, Panama  Escorted Gate 1 First Class Dates and Prices
Best of Panama with Boquete & Bocas Del Toro 14 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Boquete & San Blas Islands 13 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Pacific Coast 9 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
+ View all 28 vacations in Panama only
Multi-Country Vacations that Include Panama
Ultimate Central America 58 Mexico City, Mexico  Panama City, Panama  Escorted Intrepid Budget Dates and Prices
Best of Central America 44 Playa del Carmen, Mexico  Panama City, Panama  Escorted Intrepid Budget Dates and Prices
Amazing Central America 29 Antigua, Guatemala  Panama City, Panama  Escorted Intrepid Budget Dates and Prices
Cycle Central America 16 Granada, Nicaragua  Panama City, Panama  Escorted Intrepid Budget Dates and Prices
Volcano Adventure & Panama Highlights 28 Antigua, Guatemala  Panama City, Panama  Escorted G Adventure Budget Dates and Prices
Costa Rica & Panama Discovery 13 San Jose, Costa Rica  Panama City, Panama  Escorted Intrepid Budget Dates and Prices
Panama Experience 14 San Jose, Costa Rica  Panama City, Panama  Escorted G Adventure Budget Dates and Prices
Costa Rica & Panama Quest 16 San Jose, Costa Rica  Panama City, Panama  Escorted G Adventure Budget Dates and Prices
Costa Rica & the Panama Canal (San Jose to Panama City) 8 San Jose, Costa Rica  Panama City, Panama  Expedition Nat Hab Deluxe Dates and Prices
Costa Rica & the Panama Canal (Panama City to San Jose) 8 Panama City, Panama  San Jose, Costa Rica  Expedition Nat Hab Deluxe Dates and Prices
+ View all 28 multi-country vacations that include Panama
* Key to Quality Ratings

These vacations are classified according to the quality of accommodations, the number of included amenities and activities, and the level of service delivered.

Budget = Budget vacations that typically range from $50 to $200 per person, per day, plus airfare.
First Class = First class vacations that typically range from $80 to $350 per person, per day, plus airfare.
Deluxe = Deluxe vacations that typically range from $200 to $650 per person, per day, plus airfare.
** The prices shown are U.S. dollars per person, based on double occupancy, and subject to availability. Prices quoted for land/cruise arrangements are subject to increase without notice. Once we have received your deposit, land/cruise prices are guaranteed. Air prices quoted via phone or email are subject to increase and are guaranteed only from the time that full payment is received. Also, air prices or air promotions mentioned on this site or on the phone do not include baggage fees imposed by airlines.