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Panama Vacations

Panama, uniquely situated as a land bridge connecting North and South America, is famed for the Panama Canal that links the world's largest oceans. Many Panama tours visit the Miraflores Locks on the canal's Pacific entrance. Here, you can see millions of gallons of water transferred in mere minutes, all done by gravity.

Itineraries can also feature nocturnal wildlife cruises along the Chagres River and Gatun Lake, in search of howler monkeys, toucans and myriad reptiles; aerial tram tours through the forest canopy in Soberania National Park; and opportunities to meet the self-governing, indigenous Kuna people in the San Blas archipelago.

Book Now and Save on Panama Vacations!

  • Cyber Monday Sale! Save up to 30% off G Adventures trips. Price shown reflects discount. Expires December 6. Click here for eligible departures.
  • Save $1,000 per couple off Alexander+Roberts trips. Click here for eligible departures.
  • Save up to 25% on Hurtigruten sailings. Prices shown reflect discount. Click here for eligible departures.
  • Save with special rates on Ponant expedition cruises. Prices shown reflect discount. Click here for eligible departures.
  • Save 5% off all Monograms trips when you pay with an AMEX Gold or Platinum card . This discount is combinable with all other promotions. Click here for eligible departures.
  • Travel with Scenic and receive a Welcome Back Credit of $200 to $300 per person after your trip. The credit can be applied toward a subsequent cruise with Scenic. Click here for eligible departures.
  • AARP members save an additional $100 per couple off Collette trips. This is combinable with all offers. Click here for eligible departures.
  • Past guests of Collette save up to an additional $300 per couple when you travel within two years of the most recent trip. Click here for eligible departures.
  • Refer a new traveler to Scenic and earn a $200 to $300 per person travel credit. Each new guest also receives a $100 to $150 per person travel credit to use toward their cruise. Click here for eligible departures.
  • Save $200 per person when you book a group of six or more people on the same Alexander + Roberts trip. Other savings amounts are available for groups of three or more. Click here for eligible departures.

The vacations below are divided into two groups. First, there is a list of trips that visit only Panama, followed by a list of multi-country itineraries that include Panama.

Trips are rated according to the quality of accommodations, the number of included amenities and activities, and the level of service delivered. The vacations below are categorized according to the industry rating scale (budget, first class and deluxe). Click any vacation name for the itinerary, dates and prices.

Vacation Name Days Starts In Ends In Travel Style Company Quality*  
Vacations in Panama Only

Best of Panama 6 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama 2022 6 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with San Blas Islands 7 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with San Blas Islands 2022 7 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Pacific Coast 9 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Discover Panama: The Land Between the Seas 9 Panama City, Panama  Playa Bonita, Panama  Escorted Collette Deluxe Dates and Prices
Best of Panama with Pacific Coast 2022 9 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
The Complete Panama Canal 9 Panama City, Panama  Playa Bonita, Panama  Escorted A+R Deluxe Dates and Prices
Best of Panama with Bocas Del Toro 10 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Bocas Del Toro 2022 10 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
+ View all 18 vacations in Panama only
Multi-Country Vacations that Include Panama
Costa Rica to Panama 8 San Jose, Costa Rica  Panama City, Panama  Escorted Intrepid Budget Dates and Prices
Cruising Costa Rica and Panama - Panama to Costa Rica 8 Puerto Caldera, Costa Rica  Panama City, Panama  Other Intrepid First Class Dates and Prices
Cruising Costa Rica and Panama - Panama to Costa Rica 8 Panama City, Panama  Puerto Caldera, Costa Rica  Other Intrepid First Class Dates and Prices
Natural & Cultural History of Central America (Puerto Caldera - Colon) 8 Puerto Caldera, Costa Rica  Colon, Panama  Expedition Ponant Deluxe Dates and Prices
Costa Rica & the Panama Canal (Panama City to San Jose) 8 Panama City, Panama  San Jose, Costa Rica  Expedition Nat Hab Deluxe Dates and Prices
Costa Rica & the Panama Canal (San Jose to Panama City) 8 San Jose, Costa Rica  Panama City, Panama  Expedition Nat Hab Deluxe Dates and Prices
Between Panama and Martinique (Colón - Fort de France) 10 Colon, Panama  Fort de France, Martinique  Expedition Ponant Deluxe Dates and Prices
Panama and Colombia Discovery 10 Cartagena, Colombia  Lima, Peru  Expedition Scenic Deluxe Dates and Prices
Caribbean Sea – Discover Keys, Coves and Cultures (Itinerary 1) 11 Panama City, Panama  Miami, FL  Expedition Hurtigruten First Class Dates and Prices
Treasures of the Caribbean Sea 12 Colon, Panama  Miami, FL  Expedition Ponant Deluxe Dates and Prices
+ View all 23 multi-country vacations that include Panama
* Key to Quality Ratings

These vacations are classified according to the quality of accommodations, the number of included amenities and activities, and the level of service delivered.

Budget = Budget vacations that typically range from $50 to $200 per person, per day, plus airfare.
First Class = First class vacations that typically range from $80 to $350 per person, per day, plus airfare.
Deluxe = Deluxe vacations that typically range from $200 to $650 per person, per day, plus airfare.
** The prices shown are U.S. dollars per person, based on double occupancy, and subject to availability. Prices quoted for land/cruise arrangements are subject to increase without notice. Once we have received your deposit, land/cruise prices are guaranteed. Air prices quoted via phone or email are subject to increase and are guaranteed only from the time that full payment is received. Also, air prices or air promotions mentioned on this site or on the phone do not include baggage fees imposed by airlines.