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Panama Vacations

Panama, uniquely situated as a land bridge connecting North and South America, is famed for the Panama Canal that links the world's largest oceans. Many Panama tours visit the Miraflores Locks on the canal's Pacific entrance. Here, you can see millions of gallons of water transferred in mere minutes, all done by gravity.

Itineraries can also feature nocturnal wildlife cruises along the Chagres River and Gatun Lake, in search of howler monkeys, toucans and myriad reptiles; aerial tram tours through the forest canopy in Soberania National Park; and opportunities to meet the self-governing, indigenous Kuna people in the San Blas archipelago.

Book Now and Save on Panama Vacations!

  • Save up to 35% off G Adventures trips. Price shown reflects discount. Expires December 31. Click here for eligible departures.
  • Save up to $1,400 per couple off Collette trips. Expires December 31. Click here for eligible departures.
  • Save $1,000 per couple off select Alexander+Roberts itineraries. Expires December 31. Click here for eligible departures.
  • Hot deals! Save up to $1,500 per couple off select Collette tours. Expires December 31. Click here for eligible departures.
  • Save up to 10% on select Scenic ocean cruises. Expires December 16. Click here for eligible departures.
  • Single travelers save $500 per person off select Alexander+Roberts trips. Expires December 31. Click here for eligible departures.
  • Reduced rates with Ponant! Prices shown reflect discount. Click here for eligible departures.
  • Save 5% off all Monograms trips when you pay with an AMEX Gold or Platinum card . This discount is combinable with all other promotions. Click here for eligible departures.
  • Travel with Monograms and receive a Welcome Back Credit of $100 to $250 per person after your trip. The credit can be applied toward a subsequent trip with Monograms or its sister brands Globus, Avalon Waterways and Cosmos. Click here for eligible departures.
  • Past guests of Collette save up to an additional $300 per couple when you travel within two years of the most recent trip. Click here for eligible departures.

The vacations below are divided into two groups. First, there is a list of trips that visit only Panama, followed by a list of multi-country itineraries that include Panama.

Trips are rated according to the quality of accommodations, the number of included amenities and activities, and the level of service delivered. The vacations below are categorized according to the industry rating scale (budget, first class and deluxe). Click any vacation name for the itinerary, dates and prices.

Vacation Name Days Starts In Ends In Travel Style Company Quality*  
Vacations in Panama Only

Highlights of Panama 4 Panama City, Panama  Panama City, Panama  Independent SITA First Class Dates and Prices
Best of Panama 2020 6 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama 2021 6 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with San Blas Islands 2020 7 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with San Blas Islands 2021 7 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama 8 Panama City, Panama  Panama City, Panama  Escorted G Adventure Budget Dates and Prices
Discover Panama: The Land Between the Seas 2020 9 Panama City, Panama  Playa Bonita, Panama  Escorted Collette Deluxe Dates and Prices
Best of Panama with Pacific Coast 2020 9 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Discover Panama: The Land Between the Seas 9 Gamboa, Panama  Playa Bonita, Panama  Escorted Collette Deluxe Dates and Prices
Best of Panama with Pacific Coast 2021 9 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
+ View all 21 vacations in Panama only
Multi-Country Vacations that Include Panama
Costa Rica to Panama 8 San Jose, Costa Rica  Panama City, Panama  Escorted Intrepid Budget Dates and Prices
Cycle Costa Rica & Panama 8 San Jose, Costa Rica  Panama City, Panama  Escorted Intrepid Budget Dates and Prices
Christmas between Mexico and Panama 8 Puerto Morelos, Mexico  Colon, Panama  Expedition Ponant Deluxe Dates and Prices
Natural and Cultural History in Central America 8 Colon, Panama  Puerto Caldera, Costa Rica  Expedition Ponant Deluxe Dates and Prices
Natural & Cultural History of Central America (Puerto Caldera - Colon) 8 Puerto Caldera, Costa Rica  Colon, Panama  Expedition Ponant Deluxe Dates and Prices
Natural & Cultural History of Central America (Colon - Puerto Caldera) 8 Colon, Panama  Puerto Caldera, Costa Rica  Expedition Ponant Deluxe Dates and Prices
Wonders of Central America 2020 8 Puerto Morelos, Mexico  Colon, Panama  Expedition Ponant Deluxe Dates and Prices
Costa Rica & the Panama Canal (Panama City to San Jose) 8 Panama City, Panama  San Jose, Costa Rica  Expedition Nat Hab Deluxe Dates and Prices
Costa Rica & the Panama Canal (San Jose to Panama City) 8 San Jose, Costa Rica  Panama City, Panama  Expedition Nat Hab Deluxe Dates and Prices
Colon to Guayaquil 9 Colon, Panama  Guayaquil, Ecuador  Expedition Silversea Deluxe Dates and Prices
+ View all 37 multi-country vacations that include Panama
* Key to Quality Ratings

These vacations are classified according to the quality of accommodations, the number of included amenities and activities, and the level of service delivered.

Budget = Budget vacations that typically range from $50 to $200 per person, per day, plus airfare.
First Class = First class vacations that typically range from $80 to $350 per person, per day, plus airfare.
Deluxe = Deluxe vacations that typically range from $200 to $650 per person, per day, plus airfare.
** The prices shown are U.S. dollars per person, based on double occupancy, and subject to availability. Prices quoted for land/cruise arrangements are subject to increase without notice. Once we have received your deposit, land/cruise prices are guaranteed. Air prices quoted via phone or email are subject to increase and are guaranteed only from the time that full payment is received. Also, air prices or air promotions mentioned on this site or on the phone do not include baggage fees imposed by airlines.