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Panama Vacations

Panama, uniquely situated as a land bridge connecting North and South America, is famed for the Panama Canal that links the world's largest oceans. Many Panama tours visit the Miraflores Locks on the canal's Pacific entrance. Here, you can see millions of gallons of water transferred in mere minutes, all done by gravity.

Itineraries can also feature nocturnal wildlife cruises along the Chagres River and Gatun Lake, in search of howler monkeys, toucans and myriad reptiles; aerial tram tours through the forest canopy in Soberania National Park; and opportunities to meet the self-governing, indigenous Kuna people in the San Blas archipelago.

Book Now and Save on Panama Vacations!

  • Save up to $1,400 per couple off many Collette trips. Expires October 31. Click here for eligible departures.
  • Save up to 30% off select G Adventures departures. Price shown reflects discount. Expires October 31. Click here for eligible departures.
  • Save $1,000 per couple off select Alexander+Roberts itineraries when you pay in full at the time of booking. Click here for eligible departures.
  • Save 10% off Silversea expeditions when you pay in full. Prices shown reflect discount. Expires October 31. Click here for eligible departures.
  • Hot deals! Save up to $1,000 per couple off select Collette tours. Expires October 31. Click here for eligible departures.
  • Single supplement is waived on select Alexander + Roberts departures. Click here for eligible departures.
  • Single travelers save $500 per person off select Alexander+Roberts trips when you book and pay in full. Click here for eligible departures.
  • Reduced rates with Ponant! Prices shown reflect discount. Click here for eligible departures.
  • AARP members save an additional $100 per couple off Collette trips. This is combinable with all offers. Click here for eligible departures.
  • Last minute deals with Intrepid! Prices shown reflect discount when you pay in full at the time of booking. Click here for eligible departures.

The vacations below are divided into two groups. First, there is a list of trips that visit only Panama, followed by a list of multi-country itineraries that include Panama.

Trips are rated according to the quality of accommodations, the number of included amenities and activities, and the level of service delivered. The vacations below are categorized according to the industry rating scale (budget, first class and deluxe). Click any vacation name for the itinerary, dates and prices.

Vacation Name Days Starts In Ends In Travel Style Company Quality*  
Vacations in Panama Only

Highlights of Panama 4 Panama City, Panama  Panama City, Panama  Independent SITA First Class Dates and Prices
Best of Panama 2020 6 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama 2021 6 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama 6 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with San Blas Islands 2020 7 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with San Blas Islands 2021 7 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with San Blas Islands 7 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama 8 Panama City, Panama  Panama City, Panama  Escorted G Adventure Budget Dates and Prices
Discover Panama: The Land Between the Seas 2020 9 Panama City, Panama  Playa Bonita, Panama  Escorted Collette Deluxe Dates and Prices
Discover Panama: The Land Between the Seas 9 Gamboa, Panama  Playa Bonita, Panama  Escorted Collette Deluxe Dates and Prices
+ View all 29 vacations in Panama only
Multi-Country Vacations that Include Panama
Costa Rica to Panama 8 San Jose, Costa Rica  Panama City, Panama  Escorted Intrepid Budget Dates and Prices
Cycle Costa Rica & Panama 8 San Jose, Costa Rica  Panama City, Panama  Escorted Intrepid Budget Dates and Prices
Christmas between Mexico and Panama 8 Puerto Morelos, Mexico  Colon, Panama  Expedition Ponant Deluxe Dates and Prices
Natural and Cultural History in Central America 8 Colon, Panama  Puerto Caldera, Costa Rica  Expedition Ponant Deluxe Dates and Prices
Natural & Cultural History of Central America (Puerto Caldera - Colon) 8 Puerto Caldera, Costa Rica  Colon, Panama  Expedition Ponant Deluxe Dates and Prices
Natural & Cultural History of Central America (Colon - Puerto Caldera) 8 Colon, Panama  Puerto Caldera, Costa Rica  Expedition Ponant Deluxe Dates and Prices
Wonders of Central America 2020 8 Puerto Morelos, Mexico  Colon, Panama  Expedition Ponant Deluxe Dates and Prices
Costa Rica & the Panama Canal (Panama City to San Jose) 8 Panama City, Panama  San Jose, Costa Rica  Expedition Nat Hab Deluxe Dates and Prices
Costa Rica & the Panama Canal (San Jose to Panama City) 8 San Jose, Costa Rica  Panama City, Panama  Expedition Nat Hab Deluxe Dates and Prices
Colon to Guayaquil 9 Colon, Panama  Guayaquil, Ecuador  Expedition Silversea Deluxe Dates and Prices
+ View all 35 multi-country vacations that include Panama
* Key to Quality Ratings

These vacations are classified according to the quality of accommodations, the number of included amenities and activities, and the level of service delivered.

Budget = Budget vacations that typically range from $50 to $200 per person, per day, plus airfare.
First Class = First class vacations that typically range from $80 to $350 per person, per day, plus airfare.
Deluxe = Deluxe vacations that typically range from $200 to $650 per person, per day, plus airfare.
** The prices shown are U.S. dollars per person, based on double occupancy, and subject to availability. Prices quoted for land/cruise arrangements are subject to increase without notice. Once we have received your deposit, land/cruise prices are guaranteed. Air prices quoted via phone or email are subject to increase and are guaranteed only from the time that full payment is received. Also, air prices or air promotions mentioned on this site or on the phone do not include baggage fees imposed by airlines.