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Panama Vacations

Panama, uniquely situated as a land bridge connecting North and South America, is famed for the Panama Canal that links the world's largest oceans. Many Panama tours visit the Miraflores Locks on the canal's Pacific entrance. Here, you can see millions of gallons of water transferred in mere minutes, all done by gravity.

Itineraries can also feature nocturnal wildlife cruises along the Chagres River and Gatun Lake, in search of howler monkeys, toucans and myriad reptiles; aerial tram tours through the forest canopy in Soberania National Park; and opportunities to meet the self-governing, indigenous Kuna people in the San Blas archipelago.

Book Now and Save on Panama Vacations!

  • Save an additional $300 per couple on Scenic cruises. This deal is combinable with other offers. Expires April 30. Click here for eligible departures.
  • Save $100 to $1,000 per couple off many Collette trips. Expires April 30. Click here for eligible departures.
  • Save up to 25% off with early booking discounts on select Hurtigruten Explorer voyages. Click here for eligible departures.
  • Collette Passport Club members save an additional $100 to $150 per person off select Collette tours. Offer applies to guests who have traveled with Collette within the past two years and is combinable with other discounts. Click here for eligible departures.
  • Military members and their spouses save 5% off Scenic cruises. This offer does not apply to certain extensions. Click here for eligible departures.
  • Monograms Journeys Club members save 5% off the cruise/land price. Click here for eligible departures.
  • Save 20% when you book a group of 11 or more people on the same Intrepid trip. Other savings amounts are available for groups of nine or more. Click here for eligible departures.

The vacations below are divided into two groups. First, there is a list of trips that visit only Panama, followed by a list of multi-country itineraries that include Panama.

Trips are rated according to the quality of accommodations, the number of included amenities and activities, and the level of service delivered. The vacations below are categorized according to the industry rating scale (budget, first class and deluxe). Click any vacation name for the itinerary, dates and prices.

Vacation Name Days Starts In Ends In Travel Style Company Quality*  
Vacations in Panama Only

Discover Panama 9 Gamboa, Panama  Playa Bonita, Panama  Escorted Collette Deluxe Dates and Prices
The Complete Panama Canal 9 Panama City, Panama  Playa Bonita, Panama  Escorted A+R Deluxe Dates and Prices
Boquete + Chiriqui Highlands 3 Panama City, Panama  Panama City, Panama  Independent A+R Deluxe Dates and Prices
Discover Panama: The Land Between the Seas 2019 9 Gamboa, Panama  Playa Bonita, Panama  Escorted Collette Deluxe Dates and Prices
Best of Panama with Boquete 2019 10 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama 2019 6 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Boquete & Pacific Coast 13 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Boquete & Bocas Del Toro 14 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Boquete & San Blas Islands 13 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Pacific Coast 9 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
+ View all 25 vacations in Panama only
Multi-Country Vacations that Include Panama
Treasures of Central America (Guayaquil - Colon) 14 Guayaquil, Ecuador  Colon, Panama  Expedition Ponant Deluxe Dates and Prices
The Panama Canal & Costa Rica 2019 (Westbound) 12 Panama City, Panama  San Jose, Costa Rica  Expedition Tauck Deluxe Dates and Prices
Caribbean & Central America Treasures 17 Miami, FL  Guayaquil, Ecuador  Expedition Scenic Deluxe Dates and Prices
Treasures of the Caribbean Sea (Colón - Miami) 12 Colon, Panama  Miami, FL  Expedition Ponant Deluxe Dates and Prices
Panama, Colombia & Ecuador Discovery 8 Cartagena, Colombia  Guayaquil, Ecuador  Expedition Scenic Deluxe Dates and Prices
National Parks and Panama Canal (Puerto Caldera - Colón) 8 Puerto Caldera, Costa Rica  Colon, Panama  Expedition Ponant Deluxe Dates and Prices
The Panama Canal & Costa Rica 2019 (Eastbound) 12 San Jose, Costa Rica  Panama City, Panama  Expedition Tauck Deluxe Dates and Prices
Between Martinique and Panama (Fort de France - Colón) 10 Fort de France, Martinique  Colon, Panama  Expedition Ponant Deluxe Dates and Prices
Ultimate Caribbean & Central American Treasures 17 Miami, FL  Guayaquil, Ecuador  Expedition Scenic Deluxe Dates and Prices
Central and South American Wonders 12 Colon, Panama  Callao, Peru  Expedition Silversea Deluxe Dates and Prices
+ View all 31 multi-country vacations that include Panama
* Key to Quality Ratings

These vacations are classified according to the quality of accommodations, the number of included amenities and activities, and the level of service delivered.

Budget = Budget vacations that typically range from $50 to $200 per person, per day, plus airfare.
First Class = First class vacations that typically range from $80 to $350 per person, per day, plus airfare.
Deluxe = Deluxe vacations that typically range from $200 to $650 per person, per day, plus airfare.
** The prices shown are U.S. dollars per person, based on double occupancy, and subject to availability. Prices quoted for land/cruise arrangements are subject to increase without notice. Once we have received your deposit, land/cruise prices are guaranteed. Air prices quoted via phone or email are subject to increase and are guaranteed only from the time that full payment is received. Also, air prices or air promotions mentioned on this site or on the phone do not include baggage fees imposed by airlines.