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Panama Vacations

Panama, uniquely situated as a land bridge connecting North and South America, is famed for the Panama Canal that links the world's largest oceans. Many Panama tours visit the Miraflores Locks on the canal's Pacific entrance. Here, you can see millions of gallons of water transferred in mere minutes, all done by gravity.

Itineraries can also feature nocturnal wildlife cruises along the Chagres River and Gatun Lake, in search of howler monkeys, toucans and myriad reptiles; aerial tram tours through the forest canopy in Soberania National Park; and opportunities to meet the self-governing, indigenous Kuna people in the San Blas archipelago.

Book Now and Save on Panama Vacations!

  • Vacations To Go customers save $200 per couple on Collette vacations. Click here for eligible departures.
  • Save up to $1,200 per couple off Collette trips. Expires January 29. Click here for eligible departures.
  • Save $1,000 per couple off Alexander+Roberts trips. Click here for eligible departures.
  • Save with special rates on Hurtigruten sailings. Prices shown reflect discount. Click here for eligible departures.
  • Save with special rates on Scenic ocean sailings. Prices shown reflect discount. Click here for eligible departures.
  • Save with special rates on Ponant expedition cruises. Prices shown reflect discount. Click here for eligible departures.
  • Travel with Scenic and receive a Welcome Back Credit of $200 to $300 per person after your trip. The credit can be applied toward a subsequent cruise with Scenic. Click here for eligible departures.
  • AARP members save an additional $100 per couple off Collette trips. This is combinable with all offers. Click here for eligible departures.
  • Past guests of Collette save up to an additional $300 per couple when you travel within two years of the most recent trip. Click here for eligible departures.
  • Refer a new traveler to Scenic and earn a $200 to $300 per person travel credit. Each new guest also receives a $100 to $150 per person travel credit to use toward their cruise. Click here for eligible departures.

The vacations below are divided into two groups. First, there is a list of trips that visit only Panama, followed by a list of multi-country itineraries that include Panama.

Trips are rated according to the quality of accommodations, the number of included amenities and activities, and the level of service delivered. The vacations below are categorized according to the industry rating scale (budget, first class and deluxe). Click any vacation name for the itinerary, dates and prices.

Vacation Name Days Starts In Ends In Travel Style Company Quality*  
Vacations in Panama Only

Best of Panama 6 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Boquete 10 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with San Blas Islands 7 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Bocas Del Toro 10 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Pacific Coast 9 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Boquete & San Blas Islands 11 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Boquete & Bocas Del Toro 14 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Boquete & Pacific Coast 13 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Highlights of Panama 4 Panama City, Panama  Panama City, Panama  Independent SITA First Class Dates and Prices
Best of Panama 2022 6 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
+ View all 19 vacations in Panama only
Multi-Country Vacations that Include Panama
Ultimate America Discovery 20 Boston, MA  Cartagena, Colombia  Expedition Scenic Deluxe Dates and Prices
Caribbean Sea – Discover Keys, Coves and Cultures (Itinerary 2) 16 Miami, FL  Colon, Panama  Expedition Hurtigruten First Class Dates and Prices
Panama and Colombia Discovery 10 Cartagena, Colombia  Lima, Peru  Expedition Scenic Deluxe Dates and Prices
Panama & Colombia Discovery with Highlights of Peru 20 Cartagena, Colombia  Lima, Peru  Expedition Scenic Deluxe Dates and Prices
Colombia Experience with Panama & Colombia Discovery 18 Bogota, Colombia  Lima, Peru  Expedition Scenic Deluxe Dates and Prices
Treasures of the Caribbean Sea 12 Colon, Panama  Miami, FL  Expedition Ponant Deluxe Dates and Prices
Caribbean Sea – Discover Keys, Coves and Cultures (Itinerary 1) 11 Panama City, Panama  Miami, FL  Expedition Hurtigruten First Class Dates and Prices
Panama Experience 14 San Jose, Costa Rica  Panama City, Panama  Escorted G Adventure Budget Dates and Prices
Costa Rica & Panama Discovery 13 San Jose, Costa Rica  Panama City, Panama  Escorted Intrepid Budget Dates and Prices
Amazing Central America 29 Antigua, Guatemala  Panama City, Panama  Escorted Intrepid Budget Dates and Prices
+ View all 17 multi-country vacations that include Panama
* Key to Quality Ratings

These vacations are classified according to the quality of accommodations, the number of included amenities and activities, and the level of service delivered.

Budget = Budget vacations that typically range from $50 to $200 per person, per day, plus airfare.
First Class = First class vacations that typically range from $80 to $350 per person, per day, plus airfare.
Deluxe = Deluxe vacations that typically range from $200 to $650 per person, per day, plus airfare.
** The prices shown are U.S. dollars per person, based on double occupancy, and subject to availability. Prices quoted for land/cruise arrangements are subject to increase without notice. Once we have received your deposit, land/cruise prices are guaranteed. Air prices quoted via phone or email are subject to increase and are guaranteed only from the time that full payment is received. Also, air prices or air promotions mentioned on this site or on the phone do not include baggage fees imposed by airlines.