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Panama Vacations

Panama, uniquely situated as a land bridge connecting North and South America, is famed for the Panama Canal that links the world's largest oceans. Many Panama tours visit the Miraflores Locks on the canal's Pacific entrance. Here, you can see millions of gallons of water transferred in mere minutes, all done by gravity.

Itineraries can also feature nocturnal wildlife cruises along the Chagres River and Gatun Lake, in search of howler monkeys, toucans and myriad reptiles; aerial tram tours through the forest canopy in Soberania National Park; and opportunities to meet the self-governing, indigenous Kuna people in the San Blas archipelago.

Book Now and Save on Panama Vacations!

  • Save 10% off 2021 Collette tours. Expires October 31. Click here for eligible departures.
  • Save $1,000 per couple off Alexander+Roberts trips. Click here for eligible departures.
  • Save up to 25% on Hurtigruten sailings. Prices shown reflect discount. Click here for eligible departures.
  • Save with special rates on Ponant expedition cruises. Prices shown reflect discount. Click here for eligible departures.
  • Save 5% off all Monograms trips when you pay with an AMEX Gold or Platinum card . This discount is combinable with all other promotions. Click here for eligible departures.
  • Travel with Scenic and receive a Welcome Back Credit of $200 to $300 per person after your trip. The credit can be applied toward a subsequent cruise with Scenic. Click here for eligible departures.
  • AARP members save an additional $100 per couple off Collette trips. This is combinable with all offers. Click here for eligible departures.
  • Past guests of Collette save up to an additional $300 per couple when you travel within two years of the most recent trip. Click here for eligible departures.
  • Refer a new traveler to Scenic and earn a $200 to $300 per person travel credit. Each new guest also receives a $100 to $150 per person travel credit to use toward their cruise. Click here for eligible departures.
  • Save $200 per person when you book a group of six or more people on the same Alexander + Roberts trip. Other savings amounts are available for groups of three or more. Click here for eligible departures.

The vacations below are divided into two groups. First, there is a list of trips that visit only Panama, followed by a list of multi-country itineraries that include Panama.

Trips are rated according to the quality of accommodations, the number of included amenities and activities, and the level of service delivered. The vacations below are categorized according to the industry rating scale (budget, first class and deluxe). Click any vacation name for the itinerary, dates and prices.

Vacation Name Days Starts In Ends In Travel Style Company Quality*  
Vacations in Panama Only

Best of Panama 2021 6 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Boquete 2021 10 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with San Blas Islands 2021 7 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Bocas Del Toro 2021 10 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Pacific Coast 2021 9 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Boquete & San Blas Islands 2021 11 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Boquete & Bocas Del Toro 2021 14 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Best of Panama with Boquete & Pacific Coast 2021 13 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
Highlights of Panama 4 Panama City, Panama  Panama City, Panama  Independent SITA First Class Dates and Prices
Best of Panama 2022 6 Panama City, Panama  Panama City, Panama  Independent Monograms First Class Dates and Prices
+ View all 19 vacations in Panama only
Multi-Country Vacations that Include Panama
Ultimate America Discovery 2021 20 Boston, MA  Cartagena, Colombia  Expedition Scenic Deluxe Dates and Prices
Wonders of Central America 8 Puerto Morelos, Mexico  Colon, Panama  Expedition Ponant Deluxe Dates and Prices
Christmas between Mexico and Panama 8 Puerto Morelos, Mexico  Colon, Panama  Expedition Ponant Deluxe Dates and Prices
Christmas in the Caribbean 13 Fort de France, Martinique  Colon, Panama  Expedition Ponant Deluxe Dates and Prices
Natural & Cultural History of Central America (Puerto Caldera - Colon) 8 Puerto Caldera, Costa Rica  Colon, Panama  Expedition Ponant Deluxe Dates and Prices
Treasures of Central America 2021 (Guayaquil - Colon) 14 Guayaquil, Ecuador  Colon, Panama  Expedition Ponant Deluxe Dates and Prices
Caribbean Sea – Discover Keys, Coves and Cultures (Itinerary 2) 16 Miami, FL  Colon, Panama  Expedition Hurtigruten First Class Dates and Prices
Between Panama and Martinique 2021 (Colón - Fort de France) 10 Colon, Panama  Fort de France, Martinique  Expedition Ponant Deluxe Dates and Prices
Panama and Colombia Discovery 2021 10 Cartagena, Colombia  Lima, Peru  Expedition Scenic Deluxe Dates and Prices
Panama & Colombia Discovery with Highlights of Peru 2021 20 Cartagena, Colombia  Lima, Peru  Expedition Scenic Deluxe Dates and Prices
+ View all 28 multi-country vacations that include Panama
* Key to Quality Ratings

These vacations are classified according to the quality of accommodations, the number of included amenities and activities, and the level of service delivered.

Budget = Budget vacations that typically range from $50 to $200 per person, per day, plus airfare.
First Class = First class vacations that typically range from $80 to $350 per person, per day, plus airfare.
Deluxe = Deluxe vacations that typically range from $200 to $650 per person, per day, plus airfare.
** The prices shown are U.S. dollars per person, based on double occupancy, and subject to availability. Prices quoted for land/cruise arrangements are subject to increase without notice. Once we have received your deposit, land/cruise prices are guaranteed. Air prices quoted via phone or email are subject to increase and are guaranteed only from the time that full payment is received. Also, air prices or air promotions mentioned on this site or on the phone do not include baggage fees imposed by airlines.